Different molecular mechanisms may regulate the aging of the human body and the aging of the reproductive system, new research with worms suggests.
The findings may help explain why a woman's fertility begins to decline after age 35 but other cells in her body don't show major signs of aging until decades later, according to study author Coleen Murphy, assistant professor of molecular biology at Princeton University.
Professor Murphy and her colleagues studied the roundworms, called C. elegans, to compare the types of genes that affect lifespan and the types that keep immature egg cells (oocytes) healthy.
The findings were presented at the 2012 annual meeting of the American Society for Cell Biology, in Denver.
Research Findings
The researchers found that both body aging and reproductive aging in C. elegans involve the insulin regulation pathway, but there are marked differences in the molecular mechanisms that maintain youthful oocyte function and those that affect body ("somatic") aging.
"It seems that maintaining protein and cell quality is the most important component of somatic longevity in worms, while chromosomal/DNA integrity and cell cycle control are the most critical factors for oocyte health," Professor Murphy said.
Implications
Professor Murphy explained that finding ways to delay oocyte aging could reduce older women's risk of giving birth to a child with birth defects.
Because this study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.
Middle-Age STD
A new study found that 13% of women age 50 hand older were infected with Trichomonas vaginalis, a sexually transmitted parasite. The infection, which often causes no symptoms, is easily treated with antibiotics.
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