High Sugar Levels Can Increase Cancer Rates

Cancer may soon join diabetes and heart t disease as illnesses that are on the rise due to the obesity epidemic in this country, according to scientist.

The Study

A study looked at 10 years of data from nearly 1.3 million Korean men and women. The data came from the Korean Cancer Prevention Study, with information provided by the National Health Insurance Corporation. There were 829,770 men and 468,615 women, between the ages of 30 and 95, included in the research.

During a biennial physical, each person had his/her blood sugar level measured and was surveyed about lifestyle habits. The researchers controlled the data to account for smoking and alcohol use. People in Korea tend to be thinner and have a lower incidence of diabetes than people in the United States, according to the study.

Results

More than 56,000 people were diagnosed with cancer during the study. The incidence of cancer increased as glucose levels rose.

Overall, the risk of developing cancer was 13% higher for someone who had a fasting glucose level between 110 mg/dl and 125 mg/dl, compared with someone who had readings below 90 mg/dl. For someone who had a fasting glucose level above 140 mg/dl, the risk of cancer was 22% higher than someone whose fasting glucose level was below 90 mg/dl.

Fasting blood glucose levels are used to measure the amount of sugar in your blood after not eating or drinking for at least eight hours. A reading below 110 mg/dl is considered normal; 110-125 mg/dl is borderline; and a fasting blood glucose level more than 126 mg/dl indicates diabetes.

When the blood sugar levels of the study participants rose above 110 mg/dl, the incidence increased for leukemia and cancers of the esophagus, larynx, stomach, colon, rectum, liver, bile duct, pancreas, lung, prostate, kidney, bladder and brain, the study found.

During the study period, almost 26,000 people died from cancer. Death rates were highest for those people who had higher levels of fasting glucose. Overall, people who had fasting glucose levels higher than 140 mg/dl had a 29% greater risk of dying from cancer. For pancreatic cancer, the risk of dying was twice as great for people who had the highest fasting glucose levels compared with those who had the lowest. Only 848 of the cancer deaths occurred in people who had fasting glucose levels of less than 90 mg/dl.

Implications

"In the long run, the implication is that as the world becomes heavier and blood sugar rises, that could contribute to an increasing burden of cancer," says study co-author Dr. Jonathan Samet, chairman of epidemiology at the Johns Hopkins Bloomberg School of Public Health.

In the past, both obesity and diabetes have been linked to the development of cancer, but it was difficult to know which factor was truly responsible because most people who have diabetes are also overweight.

"It's been difficult to disentangle whether it's diabetes or obesity [that's contributing to cancer]," says American Cancer Society epidemiologist Dr. Carmen Rodriguez, who adds that because the new study was conducted on thinner people, it is especially useful.

"The size of this study is impressive," says Rodriguez, "and it probably contains a lesson for the American people-maintaining a healthy weight and a healthy lifestyle are important."

Samet agrees. "There are many reasons to be concerned about the rising waistline of the US population, and here is another untoward consequence of being overweight."

Epidemiologists from the University of Michigan Medical School say, "Since the prevalence of diabetes is higher in the United States than in Korea, it is possible that preventing diabetes may have a more important effect in the United States." They add that preventing obesity and diabetes "may ultimately diminish the burden of cancer for future generations."

More than 150 million people worldwide currently have diabetes, according to the study, and that number may double by 2025. Excess weight is a major risk factor for diabetes. In fact, according to the American Diabetes Association, nine out of 10 people newly diagnosed with type 2 diabetes are overweight.